Olivia Dunham, Fringe.
(if anyone needs convincing... watch Brown Betty, in season 2. Best. Episode. Ever.)
A very close second would be Teresa Lisbon (The Mentalist).
Book-wise... erm, does Alexia Tarabotti (Soulless, Changeless, Blameless) count? She's not really a detective, but she... investigates stuff. She's third, btw.
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Anita Blake even though she isn't technically a detective, she's a U.S. Marshal/necromancer/human servant/Lupa/a million other things and she is SAWEEEET!! Seriously Laurell K. Hamilton kicks Charlaine Harris's ass any day of the week, Bill Compton is the douchiest vampire EVER!!!
Savannah Reid from G.A. McKevett's The Savannah Reid series has to be the most satisfying detective mystery books I have read in a long time. This series features a woman who is not thin but pleasingly plump. She's a bad a** from her curly black hair to her beautiful shiny red '60 Ford Mustang (I do believe that's the year and the model-please don't beat me up if I'm wrong). She may not always get her guy or..er woman right away but she does get them in the end. Savannah is amazing to me because a) she's southern (that is the best thing ever to me), and b) despite it all (her family, her lack of romantic entanglements, her pressing need to pay her bills, etc., etc.) this chick keeps on livin' her life the way she wants to. I like that. It's kind of a philosophy that I aspire to. Keep puttin' the bad guys away Savannah!!!